Ngomhla we-15 ku-Epreli, i-2022, ukuveliswa kwe-pilot ye-Lecardipine hydrochloride main ring yagqitywa ngexesha elinye, kwaye amandla okuvelisa ngoku yi-5Mt / ngenyanga.
Igama lesiNgesi:Lercanidipine hydrochloride
Igama lomchiza:I-1,4-Dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarboxylic acid 2--[(3,3-di phenylpropyl) methylamino] -l, l-dimethylethyl methyl ester hydrochloride.
Inombolo yeCAS: 132866-11-6
Isicelo:Ngonyango lweyeza le-Lecardipine hydrochloride, aliyi kuba nefuthe elibi kwi-glucose yegazi kunye namanqanaba e-lipid, kwaye inefuthe elinamandla elichasayo.
Ithemba lemarike:
Kukho ngaphezu kwe-200 yezigidi zezigulane ze-hypertension e-China, kwaye kukho i-10 yezigidi zezigulane ezitsha ze-hypertension minyaka yonke, uninzi lwazo zingekho phantsi kolawulo, ezikhokelela kwiziganeko eziphezulu zeengxaki ze-hypertension ezifana ne-stroke, kunye nokufa ngonyaka e-China Phakathi kwe-3. izigidi zezigulane ezinesifo senhliziyo, i-50% inxulumene noxinzelelo lwegazi, kwaye iindleko zonyaka zonyango lwesifo senhliziyo malunga ne-309.8 yeebhiliyoni zeeyuan.Isizathu solawulo olulambathayo asikokuba ulwazi lwezigulane ngoxinzelelo lwegazi kunye neengxaki zalo kufuneka luphuculwe, kodwa kwakhona kukuba izigulane ezininzi ezifuna ukuthatha amayeza ubomi babo bonke azihambelani kakuhle kwaye azikwazi ukusela amayeza yonke imihla Nangona kunjalo, oku kukwabonisa ukuba Imarike yamachiza eantihypertensive inokwanda okunokwenzeka.Xa kuthelekiswa neziyobisi ezifanayo, i-locarbodipine hydrochloride inokukhetha okunamandla kwe-vascular.Ipropathi yayo ekhethekileyo ye-lipophilic yenza ukuba icothe kwaye ihlale isiphumo se-antihypertensive Isiphumo se-atherogenic, esilungele ngakumbi izigulane zoxinzelelo lwegazi kunye ne-atherosclerosis, zinexabiso eliphezulu lesicelo sekliniki kunye nethemba elibanzi lemarike.
Isenzo sePharmacological:
I-Lecardipine isizukulwana esitsha se-dihydropyridine calcium channel group hysteresis agent, enokukhetha okunamandla kwe-vascular, i-effective effect, i-antihypertensive effect, ixesha elide lesenzo, isiphumo esincinci se-inotropic kunye nokunye.Izifundo ze-in vitro zifumene ukuba i-locarbodipine inefuthe elithe ngqo lokuphumla kwi-vascular smooth muscle, kwaye ngoko ke inefuthe elinamandla le-antihypertensive kwi-vivo, kodwa inefuthe elincinci kwizinga lentliziyo kunye nesiphumo senhliziyo.Ngenxa yofuzo olukhulu lwe-hydrophobic kunye ne-lipid solubility eyomeleleyo, i-locarbodipine isasazwa ngokukhawuleza kwiithishu kunye namalungu emva kokungena emzimbeni, ngokusondeleyo kwi-vascular smooth muscle cell membrane, kwaye ikhulula ngokukhawuleza.Ngoko ke, nangona i-serum yeli chiza inexesha elifutshane lokuphelisa ukusilela kwesiqingatha, umphumo walo uhlala ixesha elide.
Ixesha lokuposa: Apr-15-2022